منابع مشابه
Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats.
Levo-tetrahydropalmatine (l-THP) is an alkaloid found in many traditional Chinese herbal preparations and has a unique pharmacological profile that includes dopamine receptor antagonism. Previously we demonstrated that l-THP attenuates fixed-ratio (FR) cocaine self-administration (SA) and cocaine-induced reinstatement in rats at doses that do not alter food-reinforced responding. This study exa...
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Cannabinoids are postulated to play a role in modulating the reinforcing effects of abused drugs, including alcohol. Experiment 1 examined alcohol self-administration in cannabinoid CB1 receptor knockout (KO), heterozygous (HT) and wild type (WT) mice in a two-bottle choice paradigm. Mice were trained in a limited 8 h access/day to 10% (v/v) EtOH (EtOH) versus water. After baseline drinking lev...
متن کاملEthanol self-administration and reinstatement of ethanol-seeking behavior in Per1 mutant mice
Rationale Alcohol consumption shows circadian rhythmicity, i.e., alcohol preference and intake change with circadian time. Circadian rhythmicity is controlled by a biological clock, which has been shown to govern behavioral, physiological, and hormonal processes in synchronization with internal as well as external cues. Molecular components of the clock include circadian clock genes such as per...
متن کاملEffects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys.
It has been hypothesized that drugs that serve as substrates for dopamine (DA) and norepinephrine (NE) transporters may be more suitable medications for cocaine dependence than drugs that inhibit DA and NE uptake by binding to transporters. Previous studies have shown that the DA/NE releaser d-amphetamine can decrease cocaine self-administration in preclinical and clinical studies. The present ...
متن کاملA Second Order Accurate Method in Simulation of Underwater Explosion
In this paper, a numerical scheme is proposed for the multi-fluid compressible flows. This method is applied to the problem of underwater explosion. The proposed scheme is basically the extension of Godunov method in gas dynamic problems to the multifluid environments and is second-order accurate in space. In this method, also, the problem of artificial mixing of two different phases on Euleria...
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ژورنال
عنوان ژورنال: Alcohol
سال: 2015
ISSN: 0741-8329
DOI: 10.1016/j.alcohol.2015.06.001